Investigation of Thermodynamic Equilibria of Vitamin C in Various Solvents Via Experimental Determination and Model Correlation
Corressponding author's email:
tamlm@hcmute.edu.vnDOI:
https://doi.org/10.54644/jte.70B.2022.1184Keywords:
SLE, Apelblat model, Vitamin C, Polythermal method, Water and alcoholsAbstract
Vitamin C plays an essential role in pharmaceutical industry. In general, the solubility of this vitamin in different environments is an important factor for drug development processes. Indeed, solid-liquid equilibrium (SLE) determination of the interested compound in various solvents needs high-precision determination which, however, frequently consumes a lot of time and labor work. In this study, we have developed a simple approach that allows detecting quickly solubility and other important thermodynamic data of dissolution processes. In fact, this approach bases on a combination of the polythermal SLE experimental-determination and the modified Apelblat model. Besides water as a single solvent, different alcohols will be used in this work. For all studied media, dissolution processes are found as endothemic with positive values of enthalpy of dissolution. Furthermore, different alkyl groups have shown influence on the solubility of this compound. Indeed, vitamin C tends to dissolve in water stronger than in ethanol and 2-propanol that relates to polarity properties and hydrogen bonding formation. The results in this contribution gain a good agreement comparing to the reported values from the literature.
Downloads: 0
References
A. K. E.-Z. El-Yafi, and H. E. Zein, “Technical crystallization for application in pharmaceutical material engineering: Review article”, Asian J. Pharm. Sci., vol. 10, no. 4, pp. 283–291, 2015.
K. Sato, Crystallization of Lipids Fundamentals and Applications in Food, Cosmetics, and Pharmaceuticals, John Wiley & Sons: Hoboken, NJ, USA, 2018.
İ. Tosun, “Solid–liquid equilibrium,” in The Thermodynamics of Phase and Reaction Equilibria, 2nd ed, Elsevier, 2021.
M. T. Le, J. V. Langermann, H. Lorenz, and A. S.-Morgenstern, “Enantiomeric 3-Chloromandelic Acid System: Binary Melting Point Phase Diagram, Ternary Solubility Phase Diagrams and Polymorphism,” Journal of Pharmaceutical Science, vol. 99, no. 9, 2010.
A. E. Lewis, M. Seckler, H. Kramer, and G. V. Rosmalen, Industrial Crystallization: Fundamentals and Applications, Cambridge University Press, 2015.
I. H. Leubner, Precision Crystallization: Theory and Practice of Controlling Crystal Size, 1st ed., CRC Press: Boca Raton, FL, USA, 2009.
J. F. Zemaitis, D. M. Clark, M. Rafal, and N. C. Scrivner, Handbook of Aqueous Electrolyte Thermodynamics Theory Application, A John Wiley & Sons, 1986.
S. Z. Mahmoudabadi and G. Pazuki, “Investigation of COSMO-SAC model for solubility and cocrystal formation of pharmaceutical compounds,” Sci Rep., vol. 10, p. 19879, 2020.
A. A. Achi, R. Greenwood, and G. Nzazi, “Pharmaceutical profile of vitamin C tablets and capsules”, Int J Pharm Compd., vol. 4, no. 5, pp. 400-3, 2000.
J. C. Bauernfeind, “The Use of Ascorbic Acid in Processing Foods”, Advances in Food Research, vol. 4, pp. 359-431, 1953.
A. C. Caritá, B. F.-Santos, J. D. Shultz, B. M.-Kohn, M. Chorilli, and G. R. Leonardi, “Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability,” Nanomedicine, 2020, vol. 24, 102117, doi: 10.1016/j.nano.2019.102117.
J. C. Bauernfeind, “Ascorbic Acid Technology in Agricultural, Pharmaceutical, Food, and Industrial Applications”, Advances in Chemistry, vol. 200, Chapter 20, 1982, pp. 395-497.
A. C. R. Neto, R. F. Pires, R. A. Malagoni; and M. Franco, “Solubility of Vitamin C in Water, Ethanol, Propan-1-ol, Water + Ethanol, and Water + Propan-1-ol at (298.15 and 308.15) K,” J. Chem. Eng. Data, vol. 55, no. 4, pp. 1718–1721, 2010.
J. Nyvlt, O. Sohnel, M. Matuchova, and M. Broul, “The kinetics of industrial crystallization”, Chemistry, Amsterdam, Elsevier, 1985.
M. T. Le, T. T. Phan, T. H. N. Nguyen, P. D. Duong, “Application of the polythermal method in constructing a quick solid-liquid equilibrium determination of l-lactide in a solvent mixture of 40% mass percentage of n-hexane in tetrahydrofuran,” Science and Technology Development Journal - Natural Sciences, vol. 5, no. 3, pp. 1474-1481, 2021.
A. Apelblat and E. Manzurola, “Solubilities of o-acetylsalicylic, 4-aminosalicylic, 3,5-dinitrosalicylic and p-toluic acid and magnesium-DL-aspartate in water from T = (278–348) K”, J. Chem. Thermodyn., vol. 31, pp. 85–91, 1999.
W. O. George, B. F. Jones and Rh. Lewis, “Water and Its Homologues: A Comparison of Hydrogen-Bonding Phenomena, Philosophical Transactions: Mathematical, Physical and Engineering Sciences,” Structures of Water and Aqueous Solutions, vol. 359, no. 1785, pp. 1611-1629, 2001.
Y. Thabet, V. Klingmann, J. Breitkreutz, “Drug Formulations: Standards and Novel Strategies for Drug Administration in Pediatrics,” Journal of Clinical Pharmacology, Sep. 2018, https://doi.org/10.1002/jcph.1138.
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2022 Journal of Technical Education Science
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © JTE.
