Hydrophobic and hydrophilic drug loading capacity of micro diatom frustule from diatomite
Corressponding author's email:
duyhanhle@hcmute.edu.vnDOI:
https://doi.org/10.54644/jte.67.2021.1087Keywords:
diatomite, micro diatom frustule, porous structure, drug loading capacity, hydrophobic and hydrophilic drugsAbstract
The aim of this work was to strengthen the evidence of using micro diatom frustule as a promising candidate for drug loading materials for both hydrophobic and hydrophilic drug models. The morphological, surface elemental composition of diatomite powder, a raw source of micro diatom frustules and purified diatomite to collect micro diatom frustule were investigated. Scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS) confirmed again the porous silica structure of micro diatom structure as well as validated a necessity of raw diatomite purification before using. UV- vis was used to measure drug loading content of untreated and treated surface of micro diatom frustule with maximum loading for hydrophobic and hydrophilic drugs after 24 hours were at 5.48 ± 0.42% and 5.70 ± 0.34, respectively. Moreover, we also proved that the ability of drug adsorption on materials surface by the reduction of specific surface area and pore size of micro diatom frustule after loading using a (Brunauer–Emmett–Teller) BET method. Besides, the hydrophobic loading capacity of materials was affected by surface modification. Based on the results, micro diatom frustule showed a potential for a drug delivery system.
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References
J. K. Patra et al., “Nano based drug delivery systems: recent developments and future prospects,” J. Nanobiotechnology, pp. 1–33, 2018. DOI: https://doi.org/10.1186/s12951-018-0392-8
A. C. Englert et al., “Pharmapolymers in the 21st Century: Synthetic Polymers in Drug Delivery Applications,” Prog. Polym. Sci., vol. 87, pp. 107–164, 2018. DOI: https://doi.org/10.1016/j.progpolymsci.2018.07.005
J. Liu, L. Cui, and D. Losic, “Acta Biomaterialia Graphene and graphene oxide as new nanocarriers for drug delivery applications,” Acta Biomater., vol. 9, no. 12, pp. 9243–9257, 2013. DOI: https://doi.org/10.1016/j.actbio.2013.08.016
Y. W. Mpharm et al., “Mesoporous silica nanoparticles in drug delivery and biomedical applications,” Nanomedicine Nanotechnology, Biol. Med., vol. 11, no. 2, pp. 313–27, 2015. DOI: https://doi.org/10.1016/j.nano.2014.09.014
M. Sumper, S. Lorenz, and E. Brunner, “Biomimetic Control of Size in the Polyamine-Directed Formation of Silica Nanospheres,” Angew. Chemie - Int. Ed., vol. 42, no. 42, pp. 5192–5195, 2003. DOI: https://doi.org/10.1002/anie.200352212
N. Kröger and E. Brunner, “Complex-shaped microbial biominerals for nanotechnology.,” Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., vol. 6, no. 6, pp. 615–27, 2014. DOI: https://doi.org/10.1002/wnan.1284
M. S. Aw, S. Simovic, Y. Yu, J. Addai-Mensah, and D. Losic, “Porous silica microshells from diatoms as biocarrier for drug delivery applications,” Powder Technol., vol. 223, pp. 52–58, 2012. DOI: https://doi.org/10.1016/j.powtec.2011.04.023
X. Zhang, H. Yang, S. Li, G. Qin, and L. Yang, “Natural diatomite particles: Size-, dose- and shape- dependent cytotoxicity and reinforcing effect on injectable bone cement,” J. Mater. Sci. Technol., 2017. DOI: https://doi.org/10.1016/j.jmst.2017.04.020
T. D. H. Le et al., “Processing and characterization of diatom nanoparticles and microparticles as potential source of silicon for bone tissue engineering,” Mater. Sci. Eng. C, vol. 59, pp. 471–479, 2016. DOI: https://doi.org/10.1016/j.msec.2015.10.040
R. M. Crawford, Y. V Likhoshway, and R. Jahn, “Morphology and identity of Aulacoseira italica and typification of Aulacoseira (Bacillariophyta),” Diatom Res., vol. 18, no. 1, pp. 1–19, 2003. DOI: https://doi.org/10.1080/0269249X.2003.9705569
M. Aivalioti, P. Papoulias, A. Kousaiti, and E. Gidarakos, “Adsorption of BTEX, MTBE and TAME on natural and modified diatomite,” J. Hazard. Mater., vol. 207–208, pp. 117–127, 2012. DOI: https://doi.org/10.1016/j.jhazmat.2011.03.040
E. Koning, M. Gehlen, A.-M. Flank, G. Calas, and E. Epping, “Rapid post-mortem incorporation of aluminum in diatom frustules: Evidence from chemical and structural analyses,” Mar. Chem., vol. 106, no. 1–2, pp. 208–222, Jul. 2007. DOI: https://doi.org/10.1016/j.marchem.2006.06.009
M. Bariana, M. S. Aw, M. Kurkuri, and D. Losic, “Tuning drug loading and release properties of diatom silica microparticles by surface modifications,” Int. J. Pharm., vol. 443, no. 1–2, pp. 230–241, 2013. DOI: https://doi.org/10.1016/j.ijpharm.2012.12.012
M. S. Aw, M. Bariana, Y. Yu, J. Addai-Mensah, and D. Losic, “Surface-functionalized diatom microcapsules for drug delivery of water-insoluble drugs.,” J. Biomater. Appl., vol. 28, no. 2, pp. 163–74, 2013. DOI: https://doi.org/10.1177/0885328212441846
U. T. Uthappa et al., “Nature engineered diatom biosilica as drug delivery systems,” J. Control. Release, vol. 281, pp. 70–83, 2018. DOI: https://doi.org/10.1016/j.jconrel.2018.05.013
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